酪酸梭菌活菌散与喜炎平注射液联用治疗婴幼儿秋冬季腹泻疗效观察

Clostridium Butyricum Powder combined with Xiyanping injection in treatment of autumn diarrhea in infants

目的观察和评价酪酸梭菌活菌散与喜炎平注射液联用治疗婴幼儿秋冬季腹泻的临床疗效。方法将73例秋冬季腹泻患儿随机分为观察组和对照组,观察组37例,喜炎平注射液5～10 mg/(kg.d)静滴,1次/d,点滴后服用酪酸梭菌活菌散,0.5 g/次,3次/d,疗程3～7 d;对照组36例,单独应用喜炎平注射液治疗。观察两组疗效和不良反应。结果观察组总有效率高达91.9%,显效率为67.6%;对照组总有效率为72.2%,显效率为44.4%,两组差异有统计学意义(P<0.05)。观察组患儿治疗第3天的大便次数明显少于对照组,大便性状恢复正常时间和呕吐消失时间亦明显短于对照组,差异有显著性意义(P<0.01)。结论酪酸梭菌活菌散与喜炎平注射液联用治疗婴幼儿秋冬季腹泻疗效显著,且未见不良反应,值得临床推广应用。

Objective To observe and evaluate the efficacy of Clostridium Butyricum Powder combined with Xiyanping injection(andrographolide injection) in treatment of autumn diarrhea in infants.Methods 73 infants with autumn diarrhea were randomly divided into two groups,observation group(37 infants) and control group(36 infants).Xiyanping injections were administered to both groups at a dose of 5-10 mg/(kg·d),and then Clostridium Butyricum Powder was administered to the observation group at a dose of 0.5 g three times a day for three to seven days.Clinical effects and side effects were observed.Results The total effective rate and significant effective rate in observation group were higher than those in control group with statistical significance(P<0.05).Improvement in stool and disappearance time of vomiting in observation group,compared the control group,were statistically significant(P<0.01).ConclusionClostridium Butyricum Powder combined with Xiyanping injection is a safe and effective method to treat autumn diarrhea in infants.