红景天、蛹虫草、大黄配伍治疗代谢综合征的实验研究Ⅱ——治疗肥胖症作用

Investigation of a compound,compatibility of Rhodiola crenulata, Cordyceps militaris,and Rheum palmatum,on metabolic syndrome treatment Ⅱ——improving obesity

利用高脂饮食诱导的胰岛素抵抗的IRF肥胖小鼠和2型糖尿病KKAy肥胖小鼠模型,观察红景天、蛹虫草、大黄配伍组成的中药复方FF16治疗肥胖症作用并初步探讨其作用机制。结果显示,FF16显著控制IRF小鼠和KKAy小鼠的体重增长;改善KKAy小鼠高TC血症和高TG血症;降低IRF小鼠的血清TC水平、增加血清HDL-C含量、减小脂肪指数。体外酶学实验显示,FF16可明显抑制分子靶点α-葡萄糖苷酶的活性。说明中药组方FF16具有明显降低肥胖小鼠体重、调节脂代谢紊乱等治疗肥胖症的作用,抑制α-葡萄糖苷酶是其作用机制之一。

To investigate the effect of compound FF16, compatibility of Rhodiola crenulata, Cordyceps militaris, and Rheum pal matum, on obesity, both the insulin resistant obese IRF mouse model induced by high fat diet and the spontaneous type 2 diabetes KKAy obese mouse model were used. The results showed that the body weights and the energy uptake were markedly reduced by com- pound FF16 in both IRF mice in dose-dependent manner and KKAy mice, respectively. Meanwhile, with the administration of FF16, the hypercholesterolemia and the hypertriglyceridemia were improved significantly in KKAy mice; and the levels of serum cholesterol and fatty index were decreased obviously, and the value of serum HDL-C was increased significantly in IRF mice, respectively. Moreo- ver, the activity of α-glycosidase was inhibited by compound FF16 in vitro. In conclusion, FF16 could improve the obesity by inhibiting α-glycosidase activity.