美常安联合聚乙二醇4000散剂对慢性功能性便秘的疗效

Effect of Medilac-S combined with macrogol 4000 powder on chronic functional constipation

目的评价美常安联合聚乙二醇4000散剂对慢性功能性便秘的疗效。方法采用随机、平行方法将慢性功能性便秘患者226例分为两组，治疗组口服美常安＋聚乙二醇4000散剂，共119例；对照组仅口服聚乙二醇4000散剂，共107例。上述两组患者疗程均为6周，其中治疗3周后将随访1次。结果治疗3周后治疗组和对照组的总有效率分别为88．3％、70.1％，治疗6周后则分别为98.3％、82.3％。治疗3周后和6周后，治疗组总有效率均高于对照组，差异有统计学意义（P〈0．05）。结论美常安联合聚乙二醇4000散剂对慢性功能性便秘的疗效优于单用聚乙二醇4000散剂，值得临床应用。

Objective To evaluate the effect of Medilac-S combined with macrogol 4000 powder on chronic functional constipation. Methods The 226 patients with chronic functional constipation were randomly divided into two groups： treatment group （ Medilac-S combined with macrogol 4000 powder group） and control group （macrogol 4000 powder group ）. The treatment lasted for 6 weeks. In this course, all the patients were followed up after the 3 weeks treatment. Results After the 3 weeks treat- ment, the total effective rates were respectively 88.3% and 70. 1% in treatment group and control group. After the 6 week treatment, the total effective rates of the two groups were 98.3% and 82.3% respective- ly. The total effective rate of treatment group was significantly higher than that of control group after the 3 or 6 weeks treatment （P 〈 0.05）. Conclusions The effect of Medilac-S combined with macrogol 4000 powder on chronic functional constipation was better than that of macrogol 4000 powder.