可溶性CD23在子宫内膜异位症患者血清和腹腔液中的表达

Soluble CD23 expression in serum and peritoneal fluid of patients with endometriosis

目的探讨可溶性CD23在子宫内膜异位症(内异症)诊断和分期中的意义。方法 2009年10月至2010年10月在吉林医药学院附属吉林油田总医院采用ELISA法对内异症患者组和对照组血清和腹腔液中可溶性CD23(sCD23)的含量进行测定,并与内异症严重程度进行相关性分析。结果子宫内膜异位症组腹腔液中sCD23含量(4.55±1.11)μg/L明显高于对照组(1.52±0.45)μg/L(P<0.05),而血清sCD23水平子宫内膜异位症组(54.77±7.23)μg/L与对照组(58.83±5.65)μg/L比较差异无统计学意义(P>0.05)。不同分期的子宫内膜异位症患者之间血清和腹腔液sCD23含量比较差异无统计学意义(P>0.05)。结论 sCD23在内异症局部免疫异常过程中可能发挥作用。

Objectives To compare soluble CD23 level in peripheral blood and peritoneal fluid between endometriosis group and control group, and between different stage of endometriosis, in order to investigate the role sCD23 played in the development of endometriosis. Methods We use ELISA to analyze the sCD23 level in peripheral blood and peritoneal fluid. Results sCD23 concentration in peritoneal fluid of endometriosis group is obviously higher than control group（P 〈 0. 05）. Conclusion sCD23 may play a potentially role in the local immunodeficiency of endometriosis patients.