宁肝调中方联合心理干预用于慢性萎缩性胃炎的临床研究

Clinical observation on combination therapy of Ninggan-Tiaozhong decoction and psychological intervention for 40 cases of chronic atrophic gastritis

目的观察宁肝调中方联合心理干预治疗慢性萎缩性胃炎（chronicatrophicgastritis，CAG）的临床疗效。方法将80例CAG患者随机分为治疗组（宁肝调中方＋心理干预）和对照组（宁肝调中方），每组40例，疗程12周。观察两组临床疗效、治疗前后症状自评量表（SCL．90）、焦虑自评量表（SAS）的变化。结果治疗12周后，治疗组总有效率为90．0％（36／40），对照组总有效率为71．8％（28／39），两组比较差异有统计学意义（x2=4．255，P〈0．05）；治疗组心理干预后SCL-90、SAS评分[分别为（39．5±4．3）分、（1.3±0．6）分]明显低于对照组[分别为（51．4±3．2）分、（1．5±0．3）分]（P〈0．05）。结论宁肝调中方联合心理干预可有效减轻CAG患者的焦虑症状，提高生活质量。

Objective To survey the clinical effect of combination therapy of Ninggan-Tiaozhong decoction and psychological intervention for chronic atrophic gastritis （CAG）. Methods 80 cases CAG were randomly divided into a treatment group （treated with Ninggan-Tiaozhong decoction and psychological intervention） and a control group （treated with Ninggan-Tiaozhong decoction）, with 40 cases in each group and performed a therapy for 12 weeks. The clinical efficacy and the change of Symptom Checklist （SCL-90） and Self-Rating Anxiety Scale（SAS） before and after treatment were evaluated. Results After 12 weeks of treatment, the total effective rate was 90.0% in the treatment group, and 74.4% in the control group. The treatment group was better than the control group（x2=4.255, P〈0.05）. After psychological intervention, SCL-90 and SAS score （39.5± 4.3, 1.3 ± 0.6） was significantly reduced in the treatment group than the control group （51.4±3.2, 1.5±0.3）, （P〈0.05）. Conclusion The combination therapy of Ninggan-Tiaozhong decoction and psychological intervention used in CAG is effective to relieve symptoms and to improve life quality of patients.