甲状腺激素水平与冠状动脉粥样硬化性心脏病的回顾性研究

Retrospective Study on the Relationship between the Level of Thyroid Hormone and Coronary Atherosclerotic Heart Disease

目的:观察冠状动脉粥样硬化性心脏病(冠心病,coronary heart disease,CHD)患者甲状腺激素水平的变化规律。方法:选取2010年至2011年在我院住院患者共299例,入选标准:年龄30岁～80岁之间;心功能I-II级;入选前未接受甲状腺激素及胺碘酮治疗。根据冠状动脉造影结果分为:对照组91例,实验组208例,实验组根据血管病变数量再分为单支血管病变组72例,双支血管病变组87例,及三支血管病变组49例,用放射免疫方法于造影前检测甲状腺激素水平,比较各组间FT3、FT4、TT3、TT4及TSH水平。结果:与对照组相比,实验组血清FT3水平下降,差异有显著统计学意义(P<0.05);其中三支血管病变组患者血浆FT3水平显著低于双支血管病变组,双支血管病变组患者血浆FT3水平显著低于单支血管病变组,差异均有统计学意义(P<0.05);各组间血清TT4、TT3、FT4、TSH水平比较无统计学差异(P>0.05)。结论:冠心病患者FT3呈低水平状态,且随着血管病变加重FT3下降越明显,检查甲状腺激素水平具有重要临床意义。

Objective： To observe the changes of the level of thyroid hormone in the patients with coronary atherosclerotic heart disease （CHD）. Methods： According to the results of coronary artery angiography, 299 patients were divided into experimental group （n=208） and control group （n=9t）. And the experimental group were divided into three sub-groups： the single vessel disease group （n=72）, the double vessel disease group （n=87） and the triple vessel disease group （n-49）. The levels of thyroid hormone were measured by radio-immunity method before coronary artery angiography, and then the levels of FT3, FT4, TT3, TT4 and TSH were compared between the two groups. Results： In comparison with the control group, the plasma level of FT3 in the experimental group was significantly declined（P〈0.05）, but no significant difference of the plasma levels ofTT4, TT3, FT4 and TSH was found between the two groups. And the plasma level of FT3 in the triple vessel disease group was significantly lower than that in double vessel group and single vessel group （P〈0.05）. Conclusion： The plasma level of FT3 was at low levels in patients with coronary atherosclerotic heart disease, which may have clinical significance for the treatment and prevention of CHD.