摘要
目的:探讨人乳头瘤病毒在银屑病合并多发鲍恩病患者皮损中的检出状况。方法:对病理确诊的一例银屑病合并多发鲍恩病的多个皮损分别进行DNA提取,采用巢式PCR方法进行HPV的DNA检测。结果:面部银屑病皮损有两种类型HPV检出,分别为HPV3型和23型,大腿部银屑病皮损中除了HPV3型和HPV23型被检出以外,尚有HPV38型,75型,82型,FA1型和FA2型等多种HPV类型被检出,阴茎部位鲍恩病皮损中有两种类型检出,分别是66型和82型。结论:银屑病长期应用免疫抑制剂治疗,可能导致HPV不显性感染,而反复多发的鲍恩病可能与多种类型的HPV感染密切相关。
Objective： To detect human papillomavirus infection in a case of psoriatic patient accompanied by multiple genital Bowen＇s disease. Methods： The DNA extractives from psoriasis and Bowen＇s disease lesions of the patient were employed for HPV DNA by nested-PCR. Results： Two types of HPV were detected from the psoriatic lesion on the face, one showed HPV3 and the other showed HPV23, besides the two types mentioned aboved, many types of HPV such as HPV38, HPV75, HPV82, HPVFA1 and HPVFA2 were detected in the psoriatic lesions on the thigh. In the Bowen＇s disease lesion of the penis, HPV66 and HPV82 were found positive. Conclusion： Application of long-term immunosupressants in the treatment of psoriasis may contribute to inapparent infection of HPV, while infection of several types of HPV may be closely associated with recurrent and multiple Bowen disease.
出处
《现代生物医学进展》
CAS
2013年第8期1500-1503,共4页
Progress in Modern Biomedicine
基金
哈尔滨医科大学附属第一医院科研基金项目(2011Y03)
关键词
银屑病
鲍恩病
人乳头瘤病毒
Psoriasis
Bowen＇s disease
Human papillomavirus
