WWOX和E2F-1在大肠癌中的表达及临床意义

Expression of the WWOX and E2F-1 in Colorectal Adenocarcinoma and Its Significance

目的:探讨WWOX和E2F-1在大肠腺癌组织中的表达及意义。方法:采用免疫组化SP法检测78例大肠腺癌、20例正常大肠粘膜、30例大肠腺瘤中WWOX和E2F-1的表达情况。结果:WWOX在大肠腺癌中的阳性率显著低于正常大肠粘膜和大肠腺瘤(P<0.05)。E2F-1在大肠腺癌中的阳性率显著高于正常大肠粘膜以及大肠腺瘤(P<0.05)。WWOX、E2F-1表达与大肠腺癌的病理分化程度、淋巴结转移和临床分期具有相关性(P<0.05)。WWOX与E2F-1基因的表达呈负相关(r=-0.323,P=0.004)。结论:WWOX和E2F-1的表达与大肠腺癌发生关系密切,是大肠腺癌发生、发展的重要生物学标记物。

Objective： To study the expression of WWOX and E2F-1 in human colorectal adenocarcinoma and its significance. Methods： The immunohistochemical SP method was used to detect 78 cases ofcolorectal adenocarcinoma, 20 cases of normal colorectal mucosa and 30 cases of colorectal adenoma with WWOX and E2F-1. Results： The positive expression rate of WWOX in esophageal carcinoma was lower than that in colorectal mucosa and colorectal adenoma （P〈0.05）. The positive expression rate of E2F-1 in esophageal carcinoma was much higher than that in colorectal mucosa and colorectal adenoma （P〈0.05）. The expressions of WWOX and E2F-1 are closely correlated with the differentiation, TNM and lymph nodes metastasis （P〈0.05）. The expression of WWOX was negatively related to that of E2F-1 in large intestine carcinoma tissues （P〈 0.05）. Conclusion： WWOX and E2F-1 are closely related to the colorectal adenocarcinoma occurrence. Both of them are important biological markers in colorectal adenocarcinoma occurrence and development.