3种治疗早期帕金森病用药方案的成本-效果分析

Cost-Effectiveness Analysis of 3 Therapeutic Schemes for Early Parkinson's Disease

目的探讨3种用药方案治疗早期帕金森病(PD)的成本-效果。方法 101例早期PD患者随机分成3组,分别给予盐酸苯海索片(A组)、多巴丝肼片(B组)、盐酸普拉克索片(C组)治疗,疗程均为12周。运用药物经济学方法分析其成本-效果。结果 A、B、C组成本分别为11.47、545.16、1 838.30元,有效率分别为62.50%、88.57%、91.18%,成本-效果比分别为18.35、615.51、2 016.12。B、C组相对于A组的增量成本-效果比分别为2 290.60、6 731.03。结论 B组用药方案治疗早期PD最佳。

Objective To discuss the cost-effectiveness of 3 therapeutic schemes in the treatment of early Parkinson＇s disease （PD）. Methods A total of 101 PD cases were randomly assigned into 3 groups： group A （Benzhexol hydrochloride tablets）, group B （Levodopa and Benserazide tablets） and group C （Pramipexole hydrochloride tablets）. After treatment for 12 weeks, the cost-effectiveness analysis was conducted for all the 3 groups. Results For group A, B and C, the costs werel 1.47, 545.16, 1 838.30 yuan, respectively; the total effective rates were 62.50%, 88.57% and 91.18%, respectively; the cost-effectiveness ratios were 18.35, 615.51, 2 016.12, respectively. The incremental cost-effectiveness ratios of group B and C were 2 290.60 and 6 731.03, respectively as against group A. Conclusion group B is the best therapeutic scheme for early PD among the 3 groups.