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小儿化脓性脑膜炎和病毒性脑炎、脑膜炎时血清和脑脊液中降钙素原变化的对比研究 被引量:11

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摘要 目的探讨小儿化脓性脑膜炎(化脑)和病毒性脑炎、脑膜炎(病脑)时血清和脑脊液中降钙素原(PCT)的变化情况,便于早期进行鉴别诊断,指导抗生素治疗。方法采用固相胶体金免疫技术,对2009年11月至2011年10月在我院神经科和儿童重症监护病房(PICU),确诊为中枢神经系统感染的47例患儿分为化脑组和病脑组(除外其他感染)进行血清和脑脊液中PCT测定,并对统计结果应用SPSS12.0进行分析。结果临床和实验室结果诊断为化脑的16例(16/47)占34%,诊断为病脑的31例(31/47)占66%,血清PCT以0.5ng/ml为阈值,相应敏感性100%,阳性预测值为76.19%,特异性为86.9%,阴性预测值为100%。脑脊液PCT以0.5ng/ml为阈值,敏感性为93.75%,特异性90.32%,阳性预测值为83.33%,阴性预测值是96.55%。结论血清PCT0.5ng/ml可作为筛选化脑和病脑的阈值,脑脊液PCT值是鉴别化脑和病脑的敏感指标。二者均可指导抗生素治疗。
出处 《中国实用医药》 2013年第10期120-121,共2页 China Practical Medicine
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二级参考文献8

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