胃癌病人血清透明质酸和可溶性白介素2受体的表达及其意义

The expression and significance of human serum hyaluronic acid and soluble interleukin-2 receptor in patients with carcinoma of stomach

为研究透明质酸（ ＨＡ） 和可溶性白介素２ 受体（ｓＩＬ－ ２ Ｒ） 与胃癌的生物学行为关系及其临床意义，用双抗体夹心法（ＥＬＩＳＡ 法） 测定４２ 例胃癌患者。３０ 例良性胃病和２４ 例健康人的ｓＩＬ－ ２Ｒ，同时还用ＲＩＡ 法测定其ＨＡ 水平。结果表明，胃癌患者血清ＨＡ 和ｓＩＬ－ ２Ｒ 明显高于良性胃病组和健康对照组（ Ｐ ＜ ０ ．０５） ，且随着胃癌病情的进展血清ＨＡ 和ｓＩＬ－ ２Ｒ 出现升高趋势，化疗后血清ＨＡ 和ｓＩＬ－ ２Ｒ 明显下降。提示血清ＨＡ 和ｓＩＬ－ ２ Ｒ 可作为胃癌的辅助诊断和病情监测的参考指标。

The relation of serum hyaluronic acid (HA) and soluble interleukin-2 receptor (sIL-2R) to the biological behavior of carcinoma of stomach were studied. The serum sIL-2R from 42 patients with carcinoma of stomach, 30 patients with benign gastropathy, 24 healthy individuals were detected by using ELISA method. Their HA levels were detected by using RIA method. It was clear that serum levels of HA and sIL-2R in patients with carcinoma of stomach were statistically higher than those in patients with benign gastropathy and in healthycontrolled group (P<0.05). With the development of carcinoma of stomach, serum HA and sIL-2R tended to increase at the same time. But serum HA and sIL-2R decreased dramatically after chemotherapy. It indicated that serum HA and sIL-2R might come as a reference index to supplementedly diagnose and moniter carcinoma of stomach.