幽门螺杆菌感染与胃粘膜肠上皮化生的关系

Correlation of helicobacter pylori infection and intestinal metaplasia in gastric mucosa

对２１１７ 例有上消化道症状患者进行幽门螺杆菌（ ＨＰ） 检测和胃粘膜活检病理学检查，ＨＰ 阳性者１４２８ 例，占６７ ．４５ ％ ，有肠化生者６２９ 例，占２９ ．７１ ％ 。ＨＰ 阳性组肠化生比阴性组更常见，分别为３２ ．８４ ％ 与２３ ．２２ ％ （ Ｐ ＜ ０ ．０１） 。这表明肠化生与年龄有关。萎缩性胃炎的ＨＰ 感染率及肠化生率明显高于浅表性胃炎组。提示ＨＰ 感染是肠上皮化生的促进因素之一，继而增加患胃癌的危险性。

patients with upper digestive tract syndrome received helicobacter pylori (HP) detection and pathologic examination of gastric mucosa biopsy. It was found that 1428 patients with positive HP, the positive rate was 67.45%; 629 with intestinal metaplasia, the positive rate was 29.71%. The patients in positive HP group were more likely to be hit with intestinal metaplasia than were those in negative group, the morbitity rates were 32.84% and 23.22%, respectively, (P<0.01). It suggested that intestinal metaplasia correlate with the ages; rates of HP infection and intestinal metaplasia in atrophic gastritis group be statistically higher than those in superficial gastritis group. It indicated that HP infection may be one of the factors to induce intestinal metaplasia and so to increase the risk of carcinoma of stomach.