摘要
目的 :观察静注不同剂量茶皂甙对正常大鼠血压水平的影响。方法 :7只雄性 SD大鼠 ,分别注射生理盐水和 5 0 mg/ kg、10 0 mg/ kg、2 0 0 mg/ kg的茶皂甙 ,连续记录血压变化。结果 :注射 3种不同剂量茶皂甙后 ,大鼠血压均出现显著下降 ,其最大降压效应与药物剂量呈显著正相关 (r=0 .796 2 ,P<0 .0 1) ,茶皂甙的降压作用存在明显量效关系 ;且随茶皂甙剂量增大 ,其降压作用持续时间延长 ,药物剂量与降压作用持续时间呈显著正相关 (r=0 .8991,P<0 .0 1) ,即茶皂甙的降压作用还存在剂量时间关系。结论
Objective:To observe the effect of theasaponin injected intravenously in different dosage on blood pressure in normal SD rats.Methods:The changes in blood pressure were continuously recorded after using normal saline+50,100,200 mg/kg theasaponin infused intravenously respectively in 7 male SD rats. Results: After infusing theasaponin in three different doses the blood pressure of all the rats was obviously decreased meanwhile there was obviously direct correlation between the theasaponin maximum hypotensive effect and the theasaponin dosage ( r = 0 796 2 , P <0 01) and a marked volumeeffect relationship.Otherwise as the dosage increased the sustained time of hypotensive effect was prolonged,the direct correlation between dosage and sustained time of hypotensive effect was obvious ( r = 0 899 1 , P <0 01),so that there was a dosagetime relationship in hypotensive effect of theasaponin.Conclusions:Theasaponin has affirmative effect on decreasing blood pressure in normal rats.
出处
《中国中西医结合急救杂志》
CAS
2000年第5期268-269,共2页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
安徽省卫生厅跨世纪人才专项基金资助项目
