不稳定型冠状动脉疾病中西医结合“序贯治疗”的研究

Study on sequential treatment with integrated traditional Chinese and western medicine for unstable coronary artery disease

目的 :探讨中西医结合“序贯治疗”对不稳定型冠状动脉疾病 (U CAD)的临床疗效。方法 :选择 42例UCAD住院患者为治疗组与同期 86例住院患者为对照组。对照组按西医常规治疗 ,治疗组在此基础上给予降纤酶、“神农益气活血”注射液 2 0 0 ml静滴治疗 ,每日 2次 ,共 7～ 10日。结果 :治疗组患者症状缓解率、心电图好转率、急性心肌梗死 (AMI)发生率及病死率均显著优于对照组 (P<0 .0 5 )。心肌酶同工酶 (CK MB)、纤维蛋白原、凝血酶原时间、部分凝血活酶时间及血小板聚集率均显著低于对照组 (P<0 .0 1)。结论 :中西医结合“序贯治疗”对 UCAD疗效显著 。

Objective:To study the clinically curative effects of sequential treatment with integrated traditional Chinese and western medicine on unstable coronary artery disease (UCAD).Methods:Fortytwo cases with UCAD were selected as treated group and 86 cases with UCAD as control group.All of them were hospitalized at the same duration.The control group was treated with conventional therapy of western medicine.In addition to the conventional treatment,the treated group was treated with defibrase.Shennong Yiqi Huoxue injection (神农益气活血注射液) 200 ml infused intravenously,for 7 to 10 days,two times per day.Results:Symptomatic remission rate and improval rate of electrocardiogram (ECG) in the treated group were significantly higher than those in control group.Meanwhile the morbidity and mortality rates of acute myocardial infarction (AMI),the level of creatine phosphokinase isoenzyme(CKMB),fibrinogen,the prothrombin time (PT),activated part thromboplastin time (APTT),platelet aggregation rate in treated group were lower than those in control group significantly( P <0 01).Conclusions:Clinically curative effects of sequential treatment with integrated traditional Chinese and western medicine on UCAD were significantly better than those with conventional therapy.