苯乙酸钠对创伤愈合作用的实验研究

Experiment Study on the Effect of Sodium Phenylacetate on the Healing of Injury

目的 :观察苯乙酸钠 (NaPA)对家兔创伤愈合的作用。方法 :用 2 4只大耳白家兔制作背部创伤模型 ,随机分为静脉用药、局部用药与对照 3组 ,每组 8只 ,实验观察至创伤后 2 1d。结果 :两用药组于创伤后第 6天起 ,创面明显比对照组缩小 (P <0 .0 5 ) ;创伤后第 15天起两用药组愈合率也明显比对照组高 (P <0 .0 5 ) ;创伤后不同时间 3组家兔纤维结合蛋白水平 (fibronectin ,Fn)组间比较无差异。结论 :苯乙酸钠静脉或局部给药对创伤愈合均有促进作用 。

Objective The experiment was designed to observe the effect of sodium phenylacetate(NaPA) on the healing of injury in rabbits.Methods The traumatic models were established on 24 white body weight 1.6～2.6 kg,which were allocated into intravenous injection group,local medication group,and control group,8 rabbits in each group.The observation was carried out for 21 days after trauma.Results The sizes of injury on day 6 after injury in 2 medicated groups were significantly smaller than those in the control group ( P <0.05);the healing rate of 2 medicated groups was significantly higher than those of control from day 15 after injury.The blood fibronectin levels in 3 groups at different days after injury did not show any significant difference.Conclusion Sodium phenylacetate has an effect on the healing of injury.No close relationship between the fibronectin levels and injury healing was found.