LDL—C／HDL—C比值对经皮冠脉介入术后患者心血管事件的预测价值

Predictive value of low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio on the cardiovascular events in patients undergoing percutaneons coronary intervention

目的评估低密度脂蛋白胆固醇（LDL—C）／高密度脂蛋白胆固醇（HDL—C）比值对经皮冠脉介入（PcI）术后患者心血管事件的预测价值。方法选择急性冠脉综合征（ACS）并予前降支置入支架的患者119例，依据血浆LDL—C／HDL—C比值将患者分为3组，随访1年，评估三组患者心血管事件发生率，以及各危险因素与心血管事件发生率的关系。结果①与LDL—C／HDL—C比值较低的两组相比，比值较高组患者体重指数、女性患者百分率、吸烟人数及糖化血红蛋白、高敏C反应蛋（hs—CRP）、总胆固醇和LDL—C水平均明显升高，而HDL—C水平和他汀类药物使用率则较低（P〈0．05）。②第1组风险（HR）1．04，95％可信区间（c，）0．98-1．08，第2组HR1．16，95％C11．08-1．20，第3组HR1．27，95％C11．19～1．36（P〈0．05）。随着LDL—C／HDL—C比值的升高，PCI术后1年患者心血管事件发生率也逐渐升高（P〈0．05）。③Cox比例风险回归模型提示，LDL—C／HDL—C比值对PCI术后心血管事件风险的预测价值优于其他危险因素。结论LDL—C／HDL—C比值对PCI术后患者1年内心血管事件再发具有一定的预测价值。

Objective To investigate the predictive value of LDL-C/HDL-C ratio on the cardiovascular events in patients with PCI treatment. Methods One hundred and nineteen patients defined as acute coronary syndrome treating with stent implantation in anterior descending artery were enrolled. According to the category of LDL-C/HDL-C ratio, patients were assigned into 3 groups and were followed up for one year to evaluate the occurrence of cardiovascular events and the relationship of cardiovascular events with risk factors. Results （1）Compared to the two low categories of LDL-C/HDL-C ratio groups, body mass index, percentage of female, number of smoker, levels of GHBAIC, hs-CRP, total cholesterol and LDL-C were higher, while level of HDL-C and us- age of statin were lower （P〈0.05）. （2）In line with the escalation of LDL-C/HDL-C ratio, the rate of cardiovascular events were gradually increased after one year followed up of PCI （P〈0.05）. （3）LDL-C/HDL-C was superior to other risk factors on the prediction of cardiovascular events after 1 year of PCI indicating by Cox proportional hazard regression. Conclusion LDL-C/HDL-C ratio had predictive value on the reoccurrence of cardiovascular events after 1 year of PCI.