川芎定痛饮对偏头痛肝风夹瘀证生活质量影响的随机对照研究

Randomized controlled study on influence of Chuangxion Dingtong Yin on quality of life in patients with syndrome of liver wind complicated by stasis of migraine

目的评价川芎定痛饮预防性治疗肝风夹瘀型偏头痛的临床疗效及对患者生存质量的影响。方法采用多中心、前瞻性、随机双盲、安慰剂对照的研究方法,治疗组86例服用川芎定痛饮免煎颗粒+必要的止痛剂,对照组42例服用安慰剂+必要的止痛剂;疗程均为12周。分别于治疗前、后,对生活质量指数及头痛发作次数进行疗效评价。结果治疗组生活质量指数总分及前景条目治疗前后差异有统计学意义(P<0.05)。2组的生活质量指数总分及前景条目的均值组间比较均有统计学差异(P<0.05)。治疗前后头痛次数差值的组间比较存在显著性差异(P<0.05)。结论川芎定痛饮预防性治疗能够有效地提高患者的生活质量并减少头痛发作次数。

Objective To review the curative effect and influence of Chuangxion Dingtong Yin in the prophylactic treatment of syndrome of liver wind complicated by stasis of migraine. Methods By applying multi-centered, perspective, randomized and double-blinded placebo-controlled method, treatment group （n=86） was orally given granules of Chuangxion Dingtong Yin and necessary analgesics for 12 weeks and control group （n=42） was orally given placebo and necessary analgesics for 12 weeks. The indexes of quality of life and times of headache attack were reviewed respectively before and after treatment. Results The difference in total index score of quality of life and average of prospective items had statistical significance between two groups （P〈0.05）. The different values in times of headache attack before and after treatment had significance between two groups （P〈0.05）. Conclusion The prophylactic treatment of migraine with Chuangxion Dingtong Yin can effectively improve quality of life and reduce times of headache attack in the patients.