急性脊髓损伤患者外周血白细胞糖皮质激素受体的变化及其意义

The changes and significance of glucocorticoid receptors in peripheral leukocytes in patients of acute spinal cord injury

目的 :探讨急性脊髓损伤患者外周血白细胞糖皮质激素受体的变化及其意义。方法 :采用放射配体结合法测定 2 0例急性脊髓损伤患者和 2 3例正常成人外周血白细胞上糖皮质激素受体结合位点。结果 :急性脊髓损伤患者受体结合位点数明显低于正常成人组。结论 :急性脊髓损伤患者外周血白细胞上糖皮质激素受体结合位点数明显减少 。

Objective:To study the changes and significance of glucocorticoid receptors in peripheral leukocytes in patients of acute spinal cord injury.Method:Glucocorticoid receptors binding sites in peripheral leukocytes from 20 patients with acute spinal cord injury and 23 normal adults were measured by radioligand binding assay.Result:Glucocorticoid receptors binding sites in peripheral leukocytes was markedly lower in patients than in normal adults.Conclusion:Glucocorticoid receptors binding sites in peripheral leukocytes from acute spinal cord injury patients decrease,which may be related to the therapy of large doses glucocorticoid to acute spinal cord injury. Author′s address\ Department of Orthopaedics,113th Hospital of PLA,Ningbo,Zhejiang,315040