兰索拉唑和雷尼替丁治疗胃溃疡疗效对比研究

Contrastive Study of Effect of Lansoprazole and Ranitidine On Treatment in Gastric Ulcer Disease

目的 :对兰索拉唑和雷尼替丁治疗胃溃疡病近期和远期愈合率进行对比研究。方法 :6 1例经内镜证实的活动性胃溃疡病 ,随机分成兰索拉唑组和雷尼替丁组 ,先行 6周治疗 ,兰索拉唑每日 30mg ,雷尼替丁 15 0mg ,每日二次 ,对愈合的 5 0例进行 1年期治疗 ,兰索拉唑每 3天 30mg ,雷尼替丁每天 15 0mg。结果 :兰索拉唑和雷尼替丁组 6周溃疡愈合率分别为 93 5 % (2 9/31例 )和 70 % (2 1/30例 ) ,1年愈合率分别为 93 1% (2 7/2 9)和 71 4%(15 /2 1例 )。结论 :兰索拉唑组治疗胃溃疡近期和远期愈合率均优于雷尼替丁组。

ObjectiveTo Study the Effect of Lansoprazole in contrast with ranitidine on healing rate in the short-term and in the long-term in gastric ulcer disease. Methods sixty-one patients with endoscopicall proven active gastric ulcer disease were randomly allocated to treatment with lansoprazole and ranitidine respectively. Lansoprazole was used in a dose of 30mg P.O. daily and ranitidine 150mg P.O. twice a day for 6 weeks. After ulcer healing, Patients (50 to date) were treated with lansoprazole (30mg P.O. for three days) and ranitidine (150mg/day P.O.) for one year long-term maintenance therapy. Results At the end of the short-term (6 weeks) treatment 93.5% (29/31) of ulcers were healed with lansoprazole vs 70% (21/30) with ranitidine. At the end of the Long-term (1 year) treatment 93.1% (27/29) of ulcers were healed with lansoprazole vs 71.4%(15/21) with ranitidine. Conclusion The treatment gastric ulcer healing rate in the short-term and in the long-term is higher with lansoprazole than ranitidine.