肝纤维化时血清I型前胶原变化规律探讨

Study the Change Regularity of serum PCI in Patients with Hepatic Fibrosis

目的 :探讨肝纤维化时血清I型前胶原 (PCI)变化规律 ,为肝纤维化的诊断筛选新的血清学指标。方法 :30例肝纤维化均经肝活检确诊 (H E染色 ,显微镜下分期 ) ,应用放免法测定血清PCI浓度。结果 :肝纤维化I和Ⅱ期PCI各为 79± 14μg/L、88± 18μg/L ,18例中阳性 4例 (2 2 2 % ) ;Ⅲ和Ⅳ期PCI分别为 118± 32 μg/L和 12 9±31μg/L ,12例中 11例阳性 (91 7% )。和正常人相比 ,肝纤维化Ⅰ和Ⅱ期PCI无差异 ,Ⅲ和Ⅳ期有显著性差异 (P <0 .0 5 ,P <0 .0 1)。结论 :PCI在肝纤维化早期升高不明显 ,晚期有显著增加 ,对是否演变成肝硬化有重要预测价值。

Objective In order to screen the new serum index in diagnosing hepatic fibrosis, We analyzed the change regularity of serum type I procollagen (PCI) in patients with hepatic fibrosis. Methods It was done examining the specimens of hepatic biopsy by H E staining, and measuring serum PCI by radioimmunoimaging. Results Serum PCI is 79±14μg/L in I stage of fibrosis ,88±18μg/L in Ⅱ stage, 118±32μg/L in Ⅲ stage, and 129±31μg/L in Ⅳ stage. There is statistical difference between Ⅲ and Ⅳstage of fibrosis group and healthy control group (P<0.05, P<0.01). Conclusion The results demonstrate that serum PCI levels markedly elevate in Ⅲ and Ⅳ stage of fibrosis, and serum PCI has an important value in differentiating cirrhosis from fibrosis.