阿霉素对兔膈肌的毒性作用

Toxicant effect of adramycin on diaphragm in rabbits

目的探讨阿霉素对膈肌的毒性作用。方法家兔随机分为对照组和阿霉素组，分别注射阿霉素和等量的生理盐水，２４ ｈ后测膈肌诱发电位（ＤＥＰ），数据经 ｔ检验。制作膈肌标本，电镜观察超微结构的变化。结果 ①阿霉素能显著降低膈肌诱发电位幅度，与对照组相比，Ｐ＜０．０１。②阿霉素可致膈肌细胞损伤，表现为肌小节Ｚ线排列不整齐、紊乱，部分Ｚ线模糊、消失，线粒体峭呈管状，空泡变性，见板层状结构。结论阿霉素对兔膈肌有毒性作用。

Objective To study the toxicant effect of adriamycin(ADM)on diaphragm in rabbits. Methods After stimulation of the bilateral phrenic nerves of rabbits,the toxicant effect of ADM on diaphram was observed and the diaphram evoked potential (DEP)was measured,and the ultrasture was observed by electron microscope. All data were evaluated by T test. Results ①Amplitude of DEP was markedly decreased in rabbits treated with ADM(P<0. 01) ②The disorder of myofibrills and swelling of mitochondria with broken cristae were observed in ADR group. Conclusions The diaphragm cell could be damaged by ADM.