非霍奇金淋巴瘤与乙型肝炎病毒感染关系的临床研究

Clinical Research of the Relationship between Non-Hodgkin's Lymphoma and Hepatitis B Virus Infection

目的:探讨四川地区非霍奇金淋巴瘤(NHL)与乙型肝炎病毒(HBV)感染的关系。方法:对160例NHL患者临床资料进行回顾性分析,应用ELISA方法测定确诊NHL时患者的乙型肝炎病毒两对半情况,并随机抽取同期住院的160例其他恶性肿瘤患者(排除原发肝细胞肝癌),160例健康体检者作为对照进行比较。结果:160例NHL患者伴HBV感染者39例(占45%),其他恶性肿瘤患者HBV感染者19例(占11.9%),健康体检者HBV感染者17例(占10.6%),与肿瘤对照组和健康对照组相比,NHL组HBV感染率高于该两组,差异有统计学意义(P<0.05)。而两对照组间比较,差异无统计学意义(P>0.05)。Ⅲ期和Ⅳ期NHL患者HBV感染率明显高于Ⅰ期和Ⅱ期患者,差异有统计学意义(P<0.05)。结论:四川地区NHL患者中HBV感染率高于一般人群和非原发性肝细胞肝癌肿瘤患者,HBV感染与NHL发病有一定相关性。

Objective： To study the relationship between non-Hodgkin＇ s lymphoma（NHL） and HBV infection in Sichuan area through retrospective analysis. Method： Serum markers of HBV were measured with ELISA technique in 160 NHL patients, 160 healthy people and 160 patients with other kinds of cancer （ except primary hepatocellular carcinoma ） in the corresponding hospitalized period, and the results were compared. Result： HBV infection rates of 160 NHL patients were significantly higher than that in two con- trol groups （P 〈 0. 05 ）. HBV infection rates at III, IV stage were significantly higher than that at stage I, II （P 〈 0. 05 ）in 160 NHL pa- tients. Conclusion： The rate of HBV infection in NHL patients is significantly higher than that in healthy people and those with other kinds of cancer in Sichuan area. HBV infection may play a role in the development of NHL.