氯吡格雷硫酸氢盐晶型Ⅰ与晶型Ⅱ的制备

Preparation of crystalline form Ⅰ and Ⅱ of clopidogrel hydrogen sulfate

目的探讨氯吡格雷硫酸氢盐晶型Ⅰ与晶型Ⅱ的制备条件。方法采用不同的溶剂、不同的温度等晶型制备方法制备晶型Ⅰ与晶型Ⅱ,并用熔点和X粉末衍射图谱进行鉴别。结果制备了氯吡格雷硫酸氢盐晶型Ⅰ与晶型Ⅱ。结论在晶型Ⅰ与晶型Ⅱ的制备中析晶温度和成盐温度对析晶过程影响较大。

[Abstract] Objective To investigate preparation condition of crystalline form Ⅰ and Ⅱ of clopidogrel hydrogen sulfate. Methods The methods of preparing the polymorphic forms adopted different solvents, temperatures and son on. The determi- nation methods of crystals were melting point and X-ray power diffraction. Results Crystal form Ⅰ and Ⅱ of clopidogel hydrogen sulfate were prepared. Conclusion The crystallization and salification temperature have great effect on crystallization in the preparation of crystal form Ⅰ and Ⅱ.