不同药物及不同时间窗溶栓治疗ST段抬高型心肌梗死的临床研究

Clinical study of thrombolytic therapy by using different drugs and within different time windows in ST segment elevation myocardial infarction

目的了解不同药物及不同时间窗溶栓治疗ST段抬高型心肌梗死的临床效果。方法回顾性分析对比发病6h内应用尿激酶溶栓治疗的42例心梗患者,发病6h内应用阿替普酶治疗的40例患者,发病在6～12h应用阿替普酶治疗的44例患者的血管再通率。结果三组患者血管再通率分别为59.5%、80.0%、29.5%,两两比较差异有统计学意义(P<0.05)。结论阿替普酶在发病6h内治疗急性ST段抬高型心肌梗死再通率高,效果优于尿激酶。而溶栓时间越早,可使更多的患者获益。

Objective To investigate the clinical effect of ST segment elevation myocardial infarction by using different drugs and within different time windows. Methods We retrospectively analyzed the blood vessel recanalization rates of the 42 patients taking urokinase within six hours after myocardial infarction, the 40 patients taking alteplase within six hours after my- ocardial infarction, and the 44 patients taking alteplase within 6-12 hours after myocardial infarction. Results The blood vessel recanalization rates of the three groups were respectively 59.5%, 80.0% and 29.5%, among which there were statistical differences between each two groups （P〈0. 05）. Conclusion The blood vessel recanalization rate is higher by using alteplase in six hours to treat the acute ST segment elevation myocardial infarction, and it is better than using urokinase. There will be more beneficiaries while the earlier of thrombolytic therapy implemented.