酮咯酸氨丁三醇与地佐辛治疗结石性肾绞痛镇痛效果比较

Comparison of analgesic effect ketorolac tromethamine and dezocine in the treatment of calculus renal colic

目的比较酮咯酸氨丁三醇与地佐辛肌肉注射治疗急性结石性肾绞痛的效果。方法将100例急性结石性肾绞痛患者随机分为A组和B组,每组各50例,分别肌肉注射酮咯酸氨丁三醇和地佐辛,观察两组的镇痛效果及不良反应。结果两组患者肌注后采用口述评分法(VRS)、视觉模拟评分法(VAS),进行镇痛效果比较,差异无统计学意义(P>0.05);A组不良反应发生率明显低于B组(P<0.05)。结论酮咯酸氨丁三醇和地佐辛肌肉注射治疗结石性肾绞痛均有较好的镇痛效果;但采用酮咯酸氨丁三醇治疗,不良反应率低,更适合急诊应用。

Objective To compare the analgesic effect of intramuscular ketorolac tromethmine and intramuscular dezocine in the treatment of acute calculus renal colic. Methods One hundred cases with acute calculus renal colic were randomly divided into intramuscular ketorolac tromethamine group A and Intramuscular dezocine group B, each group 50 cases, clinical analgesic effects and adverse reactions were observed in both groups. Results No significant difference in pain control was found between group A and group B in either the VAS or VRS for any time interval studied （P^0.05）, incidence of adverse reactions group A was significantly lower than that in group B （P〈0.05）. Conclusion Ketorolac tromethamine is a effective medication in the treatment of acute calculus renal colic, it shows similar efficacy to dezocine with a decreased number of adverse effects, it is more suitable for emergency applications.