2007-2011年福建省漳州市一般人群流行性感冒免疫水平分析

Immunization level of influenza in general population in Zhangzhou,Fujian,2007-2011

目的对福建省漳州市一般人群流行性感冒(流感)免疫水平进行分析,为流感防控提供参考依据。方法 2007-2011年共5次采集人群血清550份,以微量半致敏血凝抑制方法进行抗体检测。结果 2007-2011年甲1型(H1N1)、甲3型(H3N2)、乙型中的Yamagata系和Victorian系4型抗体阳性率差异有统计学意义,几何平均滴度(GMT)分别为1∶48.5、1∶9.9、1∶29.9和1∶31.6,有保护性抗体的比率分别是19.8%、23.6%、21.1%和7.5%。结论漳州市一般人群流感血清中4个型别抗体均达不到保护水平,存在甲1型、甲3型和乙型流感局部暴发或流行的危险。

Objective To understand the immunization level of influenza in general population in Zhangzhou, Fujian province, and provide evidence for the prevention and control of influenza. Methods A total of 550 serum samples were collected in general population in Zhangzhou from 2007 to 2011 and hemagglutination inhibition test was conducted to detect influenza virus antibody. Results The differences in antibody positive rates of Influenza A （H1N1）, influenza A （H3N2）, influenza B/Yamagata lineage and influenza B/Victorian viruses had statistical significance. The geometric mean titer（GMT） was 48.5, 9.9, 29.9 and 31.6 respectively, and the antibody protection rate was 19. 8%, 23. 6%, 21.1% and 7.5% respectively. Conclusion The antibody levels to the 4 influenza viruses were without protective effects in general population in Zhangzhou, indicating the potential of the local outbreak of influenza A（ H1N1 ）, influenza A（H3N2） and influenza B. It is necessary to strengthen the surveillance of influenza virus variants and antibody level in general population to predicate the incidence trend of influenza and provide evidence for the prevention and control of influenza.