粪钙卫蛋白检测在早产儿坏死性小肠结肠炎中的临床意义

The clinical significance of fecal calprotectin on premature infant with necrotizing enterocolitis

目的:探讨粪钙卫蛋白在坏死性小肠结肠炎(NEC)的临床意义。方法:选取2009年1月-2012年1月住院治疗的NEC 30例,以同期非NEC 30例为对照组,检测粪钙卫蛋白水平。结果:粪钙卫蛋白水平治疗前Ⅰ度(294.63±67.15)μg/g,Ⅱ度(322.00±25.23)μg/g,Ⅲ度(397.50±17.68)μg/g,对照组(187.93±55.52)μg/g,差异有显著性意义(P<0.01);治疗5 d后,Ⅰ度(201.63±64.32)μg/g,Ⅱ度(242.67±56.93)μg/g,Ⅲ度(397.79±41.42)μg/g,对照组为(145.13±33.48)μg/g,差异有显著性意义(P<0.05);治疗10 d后,Ⅰ度(122.64±40.21)μg/g,Ⅱ度(140.33±26.27)μg/g,Ⅲ度NEC中1例因肺出血死亡,对照组(101.07±28.06)μg/g,差异无显著性意义(P>0.05)。直线回归分析得出,粪便钙卫蛋白与NEC具有相关性(r=0.85,P<0.05)。结论:粪钙卫蛋白可作为早期诊断NEC的重要依据,具有临床价值。

Objective：To explore the clinical significance of fecal calprotectin in necrotizing enterocolitis（NEC）.Methods： Thirty cases with necrotizing enterocolitis（NEC） were selected from January 2009 to January 2012 and 30 non-NEC cases were taken as control group during the same period.Then the level of fecal calprotectin in these cases were tested.Results： The levels of fecal calprotectin before therapy in NEC,ⅠⅡand Ⅲwere（294.63±67.15）μg/g,（322.00±25.23）μg/g,and（397.50±17.68）μg/g respectively,while（187.93±55.52） μg/g in the control group,there were significant difference among them（P0.01）;the levels of fecal calprotectin after 5-day therapy in NECⅠ,Ⅱand Ⅲwere（201.63±64.32）μg/g,（242.67±56.93）μg/g,（397.79±41.42）μg/g respectively,and（145.13±33.48）μg/g in the control group,there were significant difference among them（P0.05）;the levels of fecal calprotectin after 10-day therapy in NECⅠandⅡwere（122.64±40.21）μg/g,（140.33±26.27）μg/g,respectively,and（101.07±28.06） μg/g in the control group,one case in NEC III died due to pulmonary bleeding,there were no significant difference among them（P0.05）.Linear regression analysis disclosed correlation between fecal calprotectin and NEC（r=0.85,P0.05）.Conclusion： Fecal calprotectin may provide an important basis for early diagnosis of NEC in clinic.