血同型半胱氨酸、叶酸、维生素B_(12)水平与脑卒中的关系研究与应用价值

The role of serum homocysteine,folate and vitamin B12 in stroke patients

目的:探讨血同型半胱氨酸(Hcy)水平与脑卒中发生的相关性,以及脑卒中患者血清叶酸(FA),维生素B12(VitB12)水平的变化。方法:分别对脑卒中患者(72例脑梗死,49例脑出血)及60名健康体检者(对照组)进行血Hcy、FA、VitB12的水平检测,并进行相关分析;另对脑卒中组其中48例血Hcy升高患者检测治疗前后血Hcy、FA、VitB12水平变化,并进行相关分析。结果:脑卒中组血Hcy水平显著高于对照组(P<0.01),而脑卒中组FA、VitB12水平则显著低于对照组(P<0.01);脑卒中组的组间血Hcy、FA、VitB12水平无差异(P>0.05);脑卒中组高Hcy血症患者血Hcy、FA、VitB12检测水平在治疗前后均有统计学意义(P<0.01)。结论:血Hcy升高与脑卒中有密切关系;血清FA、VitB12是影响血Hcy水平的原因之一。

Objective：To investigate the correlation between serum homocysteine（Hcy） levels and stroke,and the changes of serum folic acid（FA）,vitamin B12（VitB12） levels in stroke patients.Methods： Patients with stroke（72 cases of cerebral infarction,49 cases of cerebral hemorrhage）and 60 healthy people as control group were enrolled to detect the levels of Hcy,FA and VitB12 and carried out the correlation analysis.In addition,the levels of Hcy,FA and VitB12 were observed in forty-eight Hcy-increase cases before and after treatment,then the correlation analysis was conducted.Results： Hcy level was significantly higher in stroke patients than that in control group（P0.01）,while the levels of FA and VitB12 were on the contrary（P0.01）.The levels of Hcy,FA and VitB12 had no difference between cerebral infarction group and cerebral hemorrhage group（P0.05）,but showed statistical difference in Hcy-increase patients before and after treatment（P0.01）.Conclusion： The increase of serum Hcy is closely related to stroke,it may be influenced by the levels of serum FA and VitB12.