159株沙门菌血清学鉴定和耐药性分析

Analysis of serotype distribution and sensitivity of 159 Salmonella isolates

目的:了解沙门菌所致感染性腹泻的主要血清型、耐药状况及耐药谱情况,分析耐药趋势,为临床合理使用抗菌药物提供依据。方法:对2009年-2011年上海市某腹泻病监测点感染性腹泻病例中分离出的159株沙门菌进行血清学鉴定和药敏试验,并对药敏试验结果进行数据分析。结果:159株沙门菌中鉴定出11种不同的血清型,并对15种抗生素都有不同程度的耐药,其中所有菌株耐药集中在萘啶酸、氨苄西林、链霉素和四环素这4种抗菌药物,耐药率分别为75.47%、58.49%、45.28%和26.42%。159株沙门菌有50.94%为多重耐药。结论:沙门菌对抗菌药物已产生多重耐药性,合理使用抗菌药物是控制该菌耐药的关键。

Objective：To understand the main serotypes and drug resistance situation of Salmonella causing infectious diarrhea,so as to provide the basis for rational clinical use of antimicrobial drugs.Methods： One hundred and fifty-nine Salmonella isolates from infectious diarrhea patients during 2009-2011 were collected for serological identification and drug sensitivity test,then the drug sensitivity test results were analyzed.Results： Eleven serotypes were found from the 159 Salmonella isolates,showing varying drug resistance to 15 antibiotics.Nalidixic acid,ampicillin,streptomycin and tetracycline were the top four resistant antibiotics,with resistance rate of 75.47%,58.49%,45.28% and 26.42%,respectively.More than half of the 159 Salmonella isolates exhibited multi-resistance.Conclusion： Salmonella has performed multi-drug resistance to antibiotics,so rational use of antibiotics is the key to control drug resistance situation.