血清前列腺特异性抗原检测及临床意义

DETECTION OF PROSTATE SPECIFIC ANTIGEN AND ITS CLINICAL VALUE

目的 观察血清PSA水平在前列腺疾患和其它泌尿系疾病患者中的变化 ,以及对前列腺癌的诊断价值。方法 应用放射免疫分析法对 170例前列腺疾患和 140例其它泌尿系疾病患者血清中PSA进行检测。结果 正常男性和前列腺疾病及有关泌尿系疾病患者血清中均存在PSA ,但以前列腺癌患者血清PSA浓度升高最为显著 ,与正常对照者、其它前列腺疾病患者及泌尿系疾病患者之间均存在显著性差异 (P <0 .0 1)。结论 血清PSA可以用于高危人群中前列腺癌的筛查和早期诊断 ;动态观察血清PSA水平 ,可用于前列腺癌与其它疾患的鉴别诊断。

Objective To explore the changes in prostate specific antigen (PSA) of patients with prostatoses and other urinary diseases and to confirm the clinical diagnostic value of PSA detection.Methods PSA detections were made among 170 cases of prostatoses and 140 cases of other urinary diseases by using the radio-immunity analysis.Results PSA was found in both normal females and patients with prostatoses and other urinary diseases.Compared with normal cases,other cases of prostatic and urinary diseases,cases of prostatic cancer were found to have much higher PSA concentration(P<0.01).Conclusion PSA detection can be applied to the sereening and early diagnosis of prostatic cancers in high risk groups,and dynamic observation of PSA concentration can also contribute to the differential diagnosis of prostatic cancers and other diseases.