女性生殖器原发恶性黑色素瘤14例分析

Clinical analysis on 14 patients with primary melanoma in genital tract

目的 探讨女性生殖器原发性恶性黑色素瘤的临床特征。方法 对我院收治的 14例女性生殖器的原发性黑色素瘤的临床资料进行回顾性分析。结果 发生于外阴、阴道、宫颈的恶性黑色素瘤分别为 4例、9例、1例。 10例行手术切除辅以化疗和免疫疗法 ,4例单纯行化疗和免疫疗法。 14例中随访 13例。 5例生存期 <1年 ,6例 <2年 ,2例>3年 (其中一例无瘤生存 2 0年 )。结论 女性生殖器的原发性恶性黑色素瘤预后差。其治疗方法以手术为主 ,辅以化疗和免疫治疗的综合治疗。

Objective To analyse the clinical characteristics and prognosis of primary malignant melanoma in female genital tract.Methods Clinical data of 14 patients with primary malignant genital melanoma were analysed retrospectively.The tumors located in the vulva in 4patients,in vagina in 9 patients and in uterine cervix in 1 patient.Addition to chemotherapy and immunotherapy,10 patients underwent surgery,while the other 4 did not.Results All cases except one were followed up.The survival period was less than 1 year in 5 patients,less than 2 years in 6.Two lived more than 3 years and 1 more than 20 years.Conclusions The prognosis of prmary maglinant melanoma is rather poor.Surgery combined with chemotherapy and immunotherapy is the main therapeutic approach. [