恶性肿瘤患者血栓前状态的检测

Study on prethrombotic status in cancer patient

目的 对恶性肿瘤患者的血小板活化状态抗凝及纤溶部分指标进行检测 ,探讨其血栓前状态生物指标的变化。方法 采用酶联免疫法和发色底物法检测肿瘤患者 5 0例 ,正常人 30例的活化血小板α颗粒膜蛋白 (GMP 14 0 )及血浆蛋白 (PC) ,组织型纤溶酶原激活物 (t PA)及其抑制物 (PAI)含量。结果 肿瘤患者GMP 14 0、PC、t PA量显著增高 (P <0 .0 5 )PAI与正常人相近 ,(P >0 .0 5 )。结论 提示恶性肿瘤患者存在着血小板活化功能、凝血和纤溶活性增强。

Objective To evaluate platelet function and fibrinolytic activity of cancer patients.Methods ELISA and developming substrate method were used to examine the platelet alphagranule membrane protein(GMP 140)、protein C (pc),the activity of tissue type plasminogen activator (t PA) and plasminogen activator inhibitor in 50 patients and 30 healthy contrals.Results Elevated GMP 140,pc,t PA activity were detected in patient group.Conclusions there are elevated platelet activation and fibrinolgtic activity in patients with cancers. [