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局部晚期食管癌体外放射联合腔内放疗同期化疗的随机研究

External irradiation combined with intracavitary radiotherapy and concomitant chemotherapy for local adcanced esophageal carcinoma.
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摘要 目的 分析体外放射联合腔内放疗加同期化疗治疗局部晚期食管癌的疗效。方法  1995年 12月至 1997年 12月 ,88例局部晚期食管癌随机分为两组 :44例用60 Co γ射线或 6MV X射线外放射DT=5 5 2 0~ 6 0 0 0CG/4 6~ 5 0次 /2 3~ 2 5天 ;平均 3天后用192 Ir源HDR腔内放疗DT=5 0 0~ 10 0 0CGY/2~ 4次。DF方案化疗于放疗前一周开始 ,共化疗两周期 (综合组 ) ;对照组 44例单用放疗。结果 综合组 1、2、3年生存率分别为 79.2 %、33 .4%、15 .6 % ,对照组 77.3 %、36 .4%、12 .5 %。两组局部未控、复发和转移率相似 (P >0 .0 5 ) ,非癌死亡率综合组明显高于对照组 (P <0 .0 5 )。结论 体外放射联合腔内放疗加同期化疗不能进一步提高局部晚期食管癌 3年生存率。 Objective To analyze the effect of external irradiation combined with high dose rate(HDR)brachytherapy and concomitant chemotherapy for local advanced esophageal carcinoma.Methods From Dec 1995 to Dec 1997,88 patients with local advanced esophageal carcinoma were treated.They were randomly divided into combined group(44 cases) and control group (44 cases).The combined treatment consisted of external radiotherapy to a total dose of 5520~6000CGY/46~50Fraction/23~25days and brachytherapy to a total dose of 500~1000CGy/2~4 fraction.The chemotherapy regimen was a combination of cisplatinum(DDP)80~100mg/m 2 d1 and fluorouacil (5 Fu)600~700mg/m 2 d 3-7 ,The concomitant chemotherapy was carried out on days 1~7 and 29~35.The controls were treated by external radintherapy and brachytherapy without chemotherapy.Results The 1 ,2 ,3 year survival rate was 79.2%,33.4%,15.6% in the combined group respectively and 77.3%,36.4%,12.5% in control group respectively (P=0.7049).The difference of residual or recurrent cancer and metastasis in both groups was similar.The motality due to complications was statistically different between the two groups(P<0.05).Conclusions The external irradiation combined with brachytherapy and concomitant chemotherapy for local advanced esophageal carcinoma doesn′t improve 3 year survival rates. [
机构地区 四川省肿瘤医院
出处 《中国肿瘤临床与康复》 2000年第5期90-91,共2页 Chinese Journal of Clinical Oncology and Rehabilitation
关键词 食管癌 放射治疗 近距离放射治疗 local advance esophageal carcinoma radiotherapy brachytherapy chemotherapy
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