腹腔镜下子宫肌瘤剔除术中使用垂体后叶素的临床效果分析

Analysis of the Clinical Efficacy of Pituitrin in the Hysteromyomectomy under Laparoscope

目的:探讨垂体后叶素用于腹腔镜下子宫肌瘤剔除术的临床止血效果。方法:将我院妇科2011年1月至2012年6月行子宫肌瘤剔除术的120例患者随机分为三组,每组40例。Ⅰ组患者在腹腔镜术中于子宫肌层注射12IU垂体后叶素;Ⅱ组患者在腹腔镜术中于子宫肌层注射20IU缩宫素;Ⅲ组不使用任何药物。观察和比较三组患者的术中出血量和手术时间。结果:120例手术均在腹腔镜下完成,Ⅰ组和Ⅱ组术中出血量分别为(68.93±14.47)和(104.88±16.06)mL,与Ⅲ组(136.60±3.85)mL相比均明显减少(P<0.01)。Ⅰ、Ⅱ、Ⅲ组的手术时间分别为:(75.63±7.45)min、(99.46±8.45)min、(114.08±11.41)min,与Ⅲ组相比,Ⅰ、Ⅱ组患者的手术时间明显缩短(P<0.01),且Ⅰ组患者的手术时间明显短于Ⅱ组(P<0.05)。此外,Ⅰ组患者术中出血量亦显著少于Ⅱ组(P<0.01)。结论:腹腔镜下子宫肌瘤剔除术中使用垂体后叶素,可明显减少术中出血量、缩短手术时间,值得深入研究。

Objective： To evaluate the clinic hemostatic effect of pituitrin on hysteromyomectomy under laparoscope. Methods： 120 cases of patient with laparoscopic hysteromyomectomy in our gynecological department from January 2011 to June 2012 were randomly divided into three groups, 40 cases in each group. The group I was injected with pituitrin 121U under the laparoscopic operation; The group II was injected with oxytocin 20IU under the laparoscopic operation; The group III was not given any drugs. The intraoperative blood loss and operation time of the three groups were observed and compared. Results： All the operations for the 120 eases were performed under laparoscope. The intraoperative blood loss of the group I and II were 68.93±14.47 ml and 104.88±16.06 ml respectively, which were significantly less than that of group III 136.60±3.85 ml （P〈0.01）. The intraoperative time of group I and II were 75.63＋ 7.45 min and 99.46＋ 8.45 min, respectively, which were significantly shorter than that of the group Ill 114.08± 11.41 min （P〈0.01）, the intraoperative time of group I was significantly shorter than that of the group II（P〈0.05）, and the intraoperative blood loss of the group I was significantly lesser than that of the group II （P〈0.01）. Conclusion： The application of pituitrin on hysteromyomectomy under laparoscope can apparently reduce the intraoperative hemorrhage and shorten the intraoperative time, and thus is worthy of further research.