LAT1在大肠癌中的表达及其与预后的相关性研究

Expression of LAT1 in Colorectal Cancer and Its Correlation with the Prognosis

目的:研究L型氨基酸转运子1(LAT1)在大肠癌组织中的表达及其与大肠癌患者临床病理特征和预后的关系。方法:用免疫组织化学方法检测大肠癌组织和癌旁正常大肠组织中LATl的表达水平,分析大肠癌组织中LAT1的表达与大肠癌患者临床病理特征和术后生存的关系。结果:LAT1在大部分大肠癌组织中表达呈阳性,阳性率为87.1%(81/93),而在癌旁正常大肠组织的阳性表达率仅为16.13%(15/93),显著低于大肠癌组织(P<0.05)。LAT1的表达水平与大肠癌患者的临床病理参数间无显著相关性,与患者的总生存期之间的相关性也无统计学意义(P>0.05),但LAT1高表达的患者无进展生存期较低表达患者显著缩短(Log-rankP=0.046),单因素Cox回归分析表明LAT1高表达是影响大肠癌术后复发转移的潜在危险因素[HR=2.338(95%CI:0.990-5.523),P=0.053]。结论:LAT1的表达可能作为判断大肠癌患者术后复发转移风险的参考指标,LAT1高表达的大肠癌患者术后复发转移风险较高。

Objective： To evaluate the relationship between LAT1 expression and the clinicopathological characteristics as well as the prognosis of patients with colorectal cancer（CRC）.Methods： Immunohistochemistry was employed to detect the expression level of LAT1 in CRC and non-tumorous tissues.The correlation of LATl expression and clinical parameters and prognosis of CRC was analyzed.Results： The positive rate of LAT1 expression in colon cancer tissues was 87.10%（81/93）,which was 16.13%（15/93） in non-tumorous tissues.The positive rate of LAT1 expression in CRC tissues was much higher than that in non-tumorous tissues（P〈0.05）.No relationship was found between the LAT1 expression and clinical parameters as well as overall survival of colon cancer.Higher LAT1 expression was significantly associated with a poorer progression-free survival（Log-rank P = 0.046）.Univariate Cox regression analysis showed that higher expression of LAT1 was a potential risk factor predicting the relapse of CRC [HR=2.338（95% CI： 0.990-5.523）,P=0.053].Conclusion： The expression of LAT1 might be used as a potential biomarker for evaluating the relapse risk of CRC after resection.