转录因子SOX2在胆囊癌的表达及意义

Expression of Transcription Factor SOX2 in Carcinoma of Gallbladder and Its Significance

目的:研究转录因子SOX2在胆囊癌中的表达及意义。方法:收集我院自2012年1月至2012年12月间胆囊癌患者的新鲜标本42例,同时选取30例胆囊结石伴慢性胆囊炎患者的新鲜手术标本作为对照,采用用聚合酶链反应(Polymerase ChainReaction,PCR)方法,对两组患者中SOX2 mRNA的水平进行检测。结果:胆囊癌组SOX2 mRNA水平为2.9±0.5,胆囊结石伴慢性胆囊炎组为2.2±0.6,两组差异有统计学意义(P<0.05)。胆囊癌患者SOX2 mRNA的水平与TNM分期、分化程度、淋巴结转移有关(P<0.05);与年龄、性别、合并胆囊结石伴慢性胆囊炎以及肿瘤的部位大小无关,差异无统计学意义(P>0.05)。结论:转录因子SOX2可能在胆囊癌的发生、演变中发挥作用。

Objective： To study the expression of transcription factor SOX2 in carcinoma of gallbladder and discuss its clinical significance.Methods： Tissue of gallbladder from 42 cases of carcinoma and 30 cases of gallbladder stone with chronic cholecystitis were collected and detected the expression of transcription factor SOX2 by polymerase chain reaction（PCR）.Results： The relative expression of SOX2 mRNA in gallbladder carcinoma group and gallbladder stone with chronic cholecystitis group were 2.9 ±0.5 and 2.2 ± 0.6 respectively,and the difference has statistical significance（P〈0.05）.Moreover,in gallbladder carcinoma group,the level of SOX2 mRNA was related to clinical stage,pathology differentiation,lymph node metastasis（P〈0.05）,but not related to age,sex,with or without gallbladder stone and chronic cholecystitis,tumor site and size（P〈0.05）.Conclusion： SOX2 may play a role in gallbladder carcinoma cell development,differentiation and evolution.