西替利嗪联合卡介菌多糖核酸对儿童过敏性紫癜的临床疗效分析

Cetirizine Cinnarizine Combination PSN Clinical Analysis of Children Allergic Purpura

目的:观察分析西替利嗪联合卡介菌多糖核酸对儿童过敏性紫癜的临床疗效。方法:将我院从2010年1月至2011年10月我院收治的144例儿童过敏性紫癜患者随机平均分为对照组72例,应用以西替利嗪为主的常规治疗,实验组72例在对照组基础上加用卡介菌多糖核酸,治疗持续3周。检测对比治疗前后患者抗体水平,并统计计算治疗有效率;随访6个月,统计复发情况。结果:两组治疗前后血清T细胞和抗体、补体水平变化结果显示,治疗前组间差异无统计学意义(P>0.05);治疗后,实验组CD3、CD4和CD16+56上升程度大于对照组,CD8、CD19、IgA和C3、C4下降程度大于对照组,组间差异有统计学意义(P<0.05);对照组复发率为11.8%(8/68),治疗满意度为85.3%;实验组复发率为5.7%(4/70),治疗满意度为92.9%,组间差异有统计学意义(P<0.05);对照组痊愈32例,显效25例,好转7例,无效4例,治疗有效率为83.8%;实验组痊愈39例,显效27例,好转3例,无效1例,治疗有效率94.3%,组间差异有统计学意义(P<0.05)。结论:西替利嗪联合卡介菌多糖核酸能有效治疗儿童过敏性紫癜,安全高效,值得推广应用。

Objective： To observe and analyze the clinical efficacy of cetirizine Cinnarizine plus BCG polysaccharide nucleic acid on children allergic purpura.Methods： In our hospital from January 2010 to October 2011,144 cases of children with allergic purpura were randomly divided equally into control group and experimental group.72 cases in the control group were treated with Cinnarizine conventional treatment.Patients in experimental group were added with BCG polysaccharide nucleic acid treatment.Treatment lasted for three weeks.Detected and compared antibody levels in patients before and after treatment,and calculated treatment efficiency.In the 6-month follow-up,we calculated its recurrence.Results： Before treatment,there were no statistically significant difference in serum T cells and antibodies,complement levels change between the two groups（P 0.05）.After treatment,the CD3,CD4 and CD16 ＋56 levels increased greater in the experimental group than in the control group,the CD8,CD19,IgA and C3,C4 levels decreased greater in the experimental group than in the control group,and the difference was statistically significant（P 0.05）.The recurrence rate was 11.8%（8/68）,and treatment satisfaction was 85.3% in control group;whereas they were respectively 5.7%（4/70） and 92.9% in the experimental group,and the difference between the groups was statistically significant（P 0.05）.In the control group,there were 32 cases cured,25 cases showing markedly efficiency,7 cases improved,4 cases invalid,with treatment efficiency of 83.8%;In the experimental group,there were 39 cases cured,27 cases with markedly efficiency,3 cases improved,1 case invalid,with treatment efficiency of 94.3%.There was statistically significant difference between the groups（P 0.05）.Conclusion： Combination of cetirizine with Cinnarizine PSN is effective in the treatment of children allergic purpura,and should be widely applied.