期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

癌症的miRNA基因治疗 被引量：2

MiRNA Gene Therapy of Cancer
原文传递
导出
摘要 MiRNAs是一种内源非编码小RNA,具有进化上的保守性,在各物种中广泛分布。MiRNAs的作用是反向调节其靶基因的mRNA,研究发现在所有的人类癌症细胞中,miRNA的表达都有异常,即miRNA在肿瘤的形成、生长和扩散过程中发挥重要的作用。本文重点介绍了几种癌症的miRNA治疗方法,为将来的miRNA基因治疗奠定了基础。此外,还简要介绍了相关的基因传递系统及目前面临的挑战。 MicroRNAs are a class of endogenous non-coding small RNAs that are evolutionarily conserved and widely distributed among species.Their major function is to negatively regulate mRNA target genes,and miRNA expression has been shown to be deregulated in all human cancers,where miRNAs play critical roles in tumorigenesis,growth and metastasis.In this paper,we highlight several approaches by which application of miRNA in cancer treatment has created the foundation for the development of potential future miRNA therapy.In addition,we briefly illustrate gene delivery system used in miRNA therapy and obstacles at present.
作者 张金梅 李桃荣 陈静 王忠喜
机构地区 华中科技大学同济医学院附属荆州医院 荆州市第一人民医院
出处 《现代生物医学进展》 CAS 2013年第11期2172-2174,2009,共4页 Progress in Modern Biomedicine
关键词 MIRNA 癌症 基因治疗 MiRNA Cancer Gene therapy
分类号 R730.5 [医药卫生—肿瘤]
  • 相关文献

参考文献23

  • 1Zhang L, Huang J, Yang N, et al. microRNAs exhibit high frequency genomic alterations in human cancer[J]. Proc Natl Acad Sci USA, 2006,103(24):9136-9141.
  • 2Zhang L, Volinia S, Bonome T, et al. Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer[J]. Proc Natl Acad Sci USA,2008, 105(1 9):7004-7009.
  • 3Volinia S, Calin GA, Liu CG, et al. A microRNA expression signature of human solid tumors de fines cancer gene targets[J]. Proc Natl Acad Sci USA,2006,103:2257-2261.
  • 4Yanaihara N, Caplen N, Bowman E, et al. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis[J]. Cancer Cell,2006,9: 189-198.
  • 5Trang P, Medina PP, Wiggins JF, et al. Regression of murine lung tumors by the let-7 microRNA[J]. Oncogene,201O,29: 1580-1587.
  • 6Trang P, Wiggins JF, Daige CL, et al. Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice[J]. Mol Ther,2011,19:1116 -1122.
  • 7Ji J, Shi J, Budhu A, et al. MicroRNA expression, survival, and response to interferon in liver cancer[J]. N Engl J Med,2009,361: 1437-1447.
  • 8Mavrakis KJ, Van Der Meulen J, Wolfe AL, et al. A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia(T-ALL)[J]. Nat Genet,2011,43:673-678.
  • 9Hatziapostolou M, Polytarchou C, Aggelidou E et al. An HNF4a?miRNA inflammatory feedback circuit regulates hepatocellular onco?genesis[J]. Cell,2011,147:l233-1247.
  • 10Obad S, dos Santos CO, Petri A, et al. Silencing of microRNA families by seedtargeting tiny LNAs[J]. Nat Genet,2011,43:371-378.

同被引文献14

引证文献2

二级引证文献6

现代生物医学进展
2013年 第11期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部