中国林县帕金森病患者非运动症状调查

Non-motor Systems in Patients with Parkinson's Disease in Linxian County China

调查中国林县PD患者非运动症状发生状况。对中国林县PD患者和对照人群进行痴呆诊断、运动功能损害评估及其他非运动症状,包括便秘、抑郁、焦虑、睡眠评估。PD患者MMSE平均分为19(15.00～22.50)分,正常对照人群MMSE平均分21(17.25～24.00)分。两组人群时间定向和MMSE总分两组比较P<0.05,差异有统计学意义。PD患者抑郁自评分数平均为(39.43±7.95)分,正常对照人群平均分数为(33.34±9.36)分,两组之间有显著差异(P<0.05)。PD患者焦虑患病率(43.3%),与对照人群间差异不显著。38.81%PD患者便秘,与对照组之间差异不显著。PD患者常见非运动症状,以认知功能损害、抑郁、焦虑、便秘为主要表现。

To measure the prevalence of Non-movement Systems in patients with Parkinson＇ s Disease （PD） in Linxian County, China, all Parkinson＇s disease （PD） patients screened in 1999 epidemiological survey were assessed by Mini- Mental State Examination （MMSE）, self depression and anxiety scale, constipation and sleep questionnaire and Ability of Daily Life （ADL）. The mean MMSE scale were 19（15.00±22.50） and 21（17.25±24.00） in PD and normal control groups respectively and the difference was statistically significant. The mean ADL scale was 20.25 ± 11.02 in PD group and 17.16±5.58 in normal control group. The difference was significant, even layered with sex and education. Fifty- seven PD （57/69） patients were diagnosed depression with SDS, in contrast to 57 depression in normal control group （57/ 99）. The difference was significant. SAS scale was 31.15±9.41 in PD group and 32.13±9.26 in control group. There was no significant difference between the two groups. Thirty-eight point eight one percent of the PD patients （26/67） suffered constipation and 30.53 ±（29/95）of the normal control were constipation. Cognitive function and ADL were damaged in PD patients. Depression was common in PD patients and the incidences of anxiety and constipation were similar to those reported.