冠心病患者血清肺炎衣原体特异性抗体的测定

Detection of Chlamydia Pneumoniae-specific Antibodies in Sera of Patients with Chronic Coronary Heart Disease

为探讨肺炎衣原体感染与冠心病的关系 ,应用微量免疫荧光试验方法测定 45例急性心肌梗死 ,32例陈旧性心肌梗死患者和 10 1例健康对照组肺炎衣原体特异性lgG和lgM抗体。结果发现肺炎衣原体慢性感染率为 :急性心肌梗死 95 .6 % (4 3/ 45 ) ,陈旧性心肌梗死 81.3% (2 6 / 32 ) ,而对照组为 5 6 .4% (5 7/ 10 1)。LgG抗体滴度几何均数分别为 95 .6± 113 .5 ,5 1.7± 39.1和 35 .3± 33.7。急性心肌梗死和陈旧性心肌梗死患者血清肺炎衣原体慢性感染率及其抗体滴度几何均数均明显高于对照组。提示肺炎衣原体感染可能与冠心病有关。

Aim To study the association between prior infection with chlamydia pneumoniae and chronic coronary heart disease. Methods Chlamydia pneumoniae-specific lgG and lgM antibodies were measured in 45 patients with acute myocardial infarction (AMI), 32 patients with old myocardial infarction (OMI) and 101 control by microimmunofluorescence test. Results The positive rate of specific lgG antibodies was 95.6% (43/45) in patients with AMI, 81.3% (26/32) in patients with OMI and 56.4% (57/101) in controls, the geometric mean titres of spesifc lgG antibodies were 95.6±113.5, 51.7±39.1 and 35.3±33.7 respectively. The positive rate and geometric mean titres of specific lgG antibodies in patients with AMI and OMI were significantly higher than those in controls. Conclusion There may exist an association between chronic chlamydia pneumoniae infection and coronary heart disease.