肝硬化与胆结石的关系──附610例临床分析

The relationship between cirrhosis and gallstone:analysis of 610 cases

目的研究肝硬化患者胆结石发生的相关因素。方法采用Ｂ超观察６１０例肝硬化患者及５８０例无肝病对照组的肝胆系统影象学改变。结果肝硬化胆结石发生率为３３．９％（２０８／６１０），明显高于对照组１０．０％。年龄越大，肝硬化越严重，血清胆红素（ＴＢＩＬ）越高，胆结石发生率越高。未发现其它因素如性别、肝硬化的病因、谷雨转氨酶（ＡＬＴ），γ－谷氨酰转肽酶（γ－ＧＴ）、碱性磷酸酶（ＡＫＰ）、白蛋白、球蛋白的水平对胆结石发生率有影响。结论：肝硬化患者是胆结石的高发人群，其发生率与年龄、肝功能失代偿程度等因素相关。

Objective To evaluate the frequency of gallstones and related risk factors in cirrhosis patients.Methods A series of 610 cirrhotic patients and 580 patients free of liver disease were assessed for gallstones by hepatobillary raphy. Results The overall prevalence of gallstone was 33. 9% and 10. 0% for cirrhotic patients and controls respectively(P <0.01) .No relationships between gallstone and the usual risk factors, such as sex, etiology of cirrhosis, serum alanine transaminase(ALT), γ-glutamyl transpeptidase (γ-GT), alkaline phosphatase(AKP), albumin and globulin were found. On the contrary, close relations were observed with age, serum bilirubin, seventy of cirrhosis. Conclusion The prevalence of gall- gallstones is significantly higher in cirrhotic patients than that in the controls, which is associated with age and seventy of cirrhosis