新型注射用利培酮微球的药效学研究

Pharmacodynamic Study of Novel Risperidone Microspheres for Injection

制备了新型注射用利培酮微球(NRMI),采用5-HTP诱导大鼠甩头和APO诱导大鼠过度活动模型,与商品注射用利培酮微球(恒德)进行对比,评价了NRMI的药效优势.结果显示,NRMI和恒德对大鼠甩头和过度活动均有抑制作用,NRMI给药后立即起效,维持约3～4周,而恒德给药3周后起效,维持约2周.表明NR-MI起效时间早于恒德,且维持时间长于恒德,如用于临床治疗依从性可能优于恒德.

Head twitch induced by 5-HTP and hyperactivity induced by APO animal models were uesd to com- pare the pharmacodynamic advantages of novel risperidone microspheres for injection （NRMI） with those of Consta. The results showed that both NRMI and Consta could inhibite head twitch induced by 5-HTP and hyperactivity induced by APO. The effects of NRMI were shown immediately afer administration and could be sustained for 3 4 weeks, while the effects of Consta were shown 3 weeks afer administration and could be sustained for about 2 weeks. These results indicated that NRMI worked faster and longer than Consta. It would have a better compliance than Consta if used in clinical therapy.