由骨髓增生异常综合征转化伴稀有融合基因混合谱系白血病-AFX急性髓系白血病的研究
摘要
目的对1例由骨髓增生异常综合征(MDS)转化伴稀有融合基因混合谱系白血病(MLL)-AFX的急性髓系白血病(AML)患者进行确诊。方法骨髓涂片及多重反转录聚合酶链反应(RT-PCR),检测患者骨髓原始细胞比例及融合基因的表达。结果患者骨髓单个核细胞中检测到稀有融合基因MLL—AFX的表达。结论该例患者为MDS转化伴稀有融合基因MLL-AFX的AML,患者预后差。
出处
《白血病.淋巴瘤》
CAS
2013年第4期236-238,共3页
Journal of Leukemia & Lymphoma
基金
江苏省临床医学中心(ZX201102)
国家自然科学基金(81170468)
江苏省自然科学基金(BK2011266)
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