消斑汤联合阿托伐他汀治疗老年CAAP的临床观察

The clinical effects of the combination of XiaoBan Decoction and small-dose atorvastatin on gerontal patients of carotid atherosclerosis plaque.

目的观察消斑汤(自拟)联合阿托伐他汀治疗老年人颈动脉粥样硬化斑块(CAAP)及逆转颈动脉内-中膜厚度(IMT)的临床效果。方法确诊的90例患者随机分为西药组、中药组与中西结合组各30例,西药组口服阿托伐他汀20mg/n;中药组口服消斑汤,1剂/d;中西结合组口服消斑汤1剂/d,阿托伐他汀20mg/n。三组均以3个月为1疗程,治疗2个疗程。结果三组患者的颈动脉粥样硬化斑块(CAAP),逆转颈动脉内-中膜厚度(IMT),血脂代谢较治疗前均有不同程度的改善,并且中西医结合组的疗效明显优于中药组和西药组。结论中西结合治疗老年人颈动脉粥样硬化斑块(CAAP)及逆转颈动脉内-中膜厚度(IMT)的疗效优于单纯使用西药组或中药组治疗。

Objective To observe the clinical effects of the combination of XiaoBan Decoction and small-dose atorvastatin on gerontal patients of carotid atherosclerosis plaque （CAAP） and reversing Carotid intima-media thickness （IMT）. Methods 90 diagnosed patients were randomly divided into three groups： control group（ treated with atorvastatin 20 rag/night）, XiaoBan decoction group （treated with XiaoBan decoction, 1/ day） and XiaoBan decoction plus small-dose atorvastatin group（ treated with atorvastatin 20 mg/night and XiaoBan decoctin 1/day）, three months were a course of treatment and all groups were acept two courses of treatment. Results The CAAP, IMT and the blood lipid metabolism of all three group＇s patients have varying degrees improvement and moreover the XiaoBan decoctin plus small-dose atorvastatin group have significantly effect better than control group or XiaoBan decoctin only group. Conclusion The clinical effect of combination of XiaoBan decoctin and small-dose atorvastatin on carotid atherosclerosis plaque （CAAP） and reversing Carotid intima-media thickness（IMT） are more effective than simply using the atorvastatin or XiaoBan Decoction in gerontal patients.