男性阻塞性睡眠呼吸暂停综合征与代谢综合征及糖代谢相关性研究

Study on the relevance between obstructive sleep apnea syndrome and metabolic syndrome & glucose metabolism disorders in male

目的探讨男性阻塞性睡眠呼吸暂停综合征(OSAHS)与代谢综合征(MS)及糖代谢紊乱的相关性。方法将男性鼾症者102例分为单纯性鼾症者(对照组)及OSAHS组,根据呼吸暂停低通气指数(AHI)将OSAHS组进一步分为轻中度组和重度组,比较对照组和各亚组间MS的发病率及糖代谢情况。测量多导睡眠监测参数、外周循环中代谢参数和人体某些参数,分析各参数在对照组及各亚组之间的差异性和相关性。结果 OSAHS亚组中MS、糖耐量减退及糖尿病发病率均显著高于对照组;单因素逐步Logistic回归分析显示AHI为MS的危险因素;多因素逐步Logistic回归分析显示AHI和MS发病独立相关。结论 OSAHS是MS的独立危险因素,是糖代谢紊乱的危险因素。

Objective To study the relevance between obstructive sleep apnea hyponea syndrome （OSAHS） and metabolic syndrome（MS） ＆ glucose metabolic disorder in male. Methods Through PSG examination, 102 male habitual snorers were divided into simple snorers （control group） and OSAHS groups who were further divided into mild-to-moderate and severe OSAHS groups based on AHI. The incidences of MS and glucose metabolic disorder were compared among different groups. All cases of PSG parameters, fasting blood sampiing as well as some measurement of anthropometric variables were measured. Results Compared with control group, the incidence of MS and glucose metabolic disorders was significantly higher in OSAHS groups. Conclusion An increase in AHI is independently associated with an increase in the incidence of MS after adjusting for confounders. OSAHS is associated with glucose metabolic disorder.