大量放腹水加输白蛋白治疗肝硬化难治性腹水疗效观察及安全性探讨

Large volume paracentesis plus albumin in the treatment of refractory cirrhotic ascites efficacy and safety study

目的探讨大量放腹水加输注白蛋白治疗肝硬化难治性腹水的临床疗效及安全性。方法 93例符合难治性肝硬化腹水患者随机分研究组47例及对照组46例,研究组采用大量放腹水:每次1000～5000ml加输注白蛋白,对照组采用利尿剂和少量放腹水治疗,观察两组腹水完全消退时间、并发症及住院时间。结果研究组腹水完全消退时间、住院时间明显短于对照组(P<0.5);并发症的的发生率也明显比对照组少(P<0.5),结论大量放腹水加输白蛋白治疗肝硬化难治性腹水较安全有效,应作为该类患者在不能进行肝移植时的治疗方法首选。

Objective To investigate the clinical efficacy and safety of large volume paracentesis plus albumin infusion in the treatment of refractory cirrhotic aseites. Methods 93 patients with refractory ascites due to cirrhosis patients were randomly divided into study group 47 eases and control group 46 cases, study group was treated with large volume paraeentesis plus albumin infusion： every time 1000 -5000 ml, control group with diuretics and a small amount of ascites treatment, observes two groups of ascites completely subsided, complications and hospitalization time. Results The study group with complete regression time, hospitalization time was shorter than the control group （ P 〈 0. 5 ）, the incidence of complications is significantly less than the control group （ P 〈 0. 5 ）, Conclusion Large volume paraeentesis plus albumin in the treatment of refractory cirrhotic ascites is safe and effective, should be used as the treatment method of the liver transplantation in patients not preferred.