影响卵巢移植中血管生成因素的研究进展

Progress of the Influence Factors of Angiogenesis in Ovary Transplantation

随着诊疗技术的发展,女性肿瘤患者的生存时间逐渐延长。但手术及放化疗在一定程度上可能会导致卵巢功能的衰退。此外,部分女性患者并不适合体内促排卵的操作。因此,卵巢移植就成为一个很有前景的研究方向。卵巢移植的目的是通过减少始基卵泡和卵母细胞的丢失,以优化卵泡发育来保存生殖功能。但移植的卵巢组织通常在移植后早期就受到缺血的损伤。因此,缩短缺血时间、加速血管生成是一个亟待解决的问题。卵巢组织的血管生成常受到组织体积、移植部位、有无冻存、促性腺激素的运用、血管内皮生长因子(VEGF)、手术性创伤等多方面因素的影响。综述影响卵巢移植后血管生成的因素以及提高卵巢组织移植后生存率和卵泡发育的研究进展。

Advances in the diagnosis and treatment has gradually increased the long-term survival rates of female cancer patients. Unfortunately,operation and chemo/radiotherapy can result in ovarian failure. Besides,part of the female patients is not suitable for ovulation in vivo. Therefore ovarian transplantation is being a promising research. The major objective of ovarian transplantation is to preserve fertility by minimizing loss of primordial follicles and oocytes and optimizing follicular develop- ment. Transplanted fragments of the ovaries are prone to ischemic damage during the early period after transplantation. Thus, reducing the duration of ischemia and accelerating graft revascularization is the urgent challenge. The angiogenesis of the ovarian tissue is influenced by the size of graft,the site of transplantation,freeze-stored or not,the usage of gonadotropin,VEGF, surgical wounds and so on. This review will have a comprehensive introduction into the influence factors of angiogenesis which provide the reference for improving the survival rate of graft and follicles development.