脱氢表雄酮在卵巢储备功能低下患者中的应用

Dehydroepiandrosterone Supplementation in Diminished Ovarian Reserve

现今社会女性生育年龄明显推后,这也让卵巢储备功能成为影响妊娠的一个重要因素。目前世界范围内近三分之一的辅助生殖中心在卵巢储备功能低下(DOR)患者中应用脱氢表雄酮(DHEA),为DOR患者的治疗提供了新思路。据报道,DHEA在改善DOR患者获卵率及改善妊娠结局方面的作用明显。但是由于研究方法不够严谨和样本量较小等原因,这些研究没有得到广泛的认可。关于DHEA应用的安全性以及治疗量等方面也缺乏证据。DHEA在DOR患者中的临床研究需要大量设计科学严谨的前瞻性随机对照试验。综述DHEA在DOR患者中的应用。

As a result of temporary social trends ,many women select to postpone their first pregnancy to a later stage in life. A large part of this population will be infertile by the time they decide to conceive, mainly because of a decreasing ovarian reserve （DOR）and low ooeyte quality resulting from age. Dehydroepiandrosterone （DHEA）is now utilized in approximately one third of all IVF centers world wide, which provide a new idea for the treatment of patients with poor ovarian function.It has been reported to improve oocytes yields and pregnancy rate with DOR. However, these studies have not been widely recognized due to the drawbacks of the research methods and the small sample size. Increasing DHEA utilization and publication of a first prospectively randomized trial now warrants a systematic review.