摘要
抗苗勒管激素(AMH)是转化生长因子β超家族成员之一,在胚胎发育的性别分化过程中起着重要作用。女性体内的AMH仅由颗粒细胞分泌,通过与靶器官上的抗苗勒管激素受体(AMHR)特异性结合发挥作用。血AMH水平能反映卵泡池的大小,可作为检测卵巢储备功能的指标,并在辅助生殖中有重要的应用价值。越来越多的研究认为,血AMH水平的升高可作为卵巢颗粒细胞瘤的肿瘤标记物用于其诊断及复发的监测,并且AMH对卵巢上皮性癌细胞株的生长、侵袭和转移有抑制作用,未来很有可能作为卵巢癌化疗的新药物。
Anti-Müllerian hormone （AMH） belongs to the transforming growth factor-β （TGF-β） superfamily, and it plays an important role in male sex differentiation. In women,it is only produced by the granulosa cells （GC） and exerted through specific receptors which are present on the target-organs. AMH level in serum can accurately reflect the size of ovarian follicle pool, so it may be an idea marker of ovarian reserve, and may also be a valuable tool in assisted reproduction technology. More and more investigations show that the elevation of AMH level in serum may be a candidate marker for the diagnosis of granulosa cell tumors and monitor the clinical recurrence of tumor. Moreover, AMH inhibits cell proliferation, invasion and mi- gration of epithelial ovarian cancer cell lines, and it can probably be used as a new drug for chemotherapy in the future.
出处
《国际妇产科学杂志》
CAS
2013年第2期123-125,133,共4页
Journal of International Obstetrics and Gynecology
基金
上海市科学技术委员会科研计划项目课题(10140901501)
关键词
卵巢
性腺甾类激素
生殖技术
辅助
颗粒细胞瘤
卵巢肿瘤
癌
Ovary
Gonadal steroid hormones
Reproductive techniques, assisted
Granulosa cell tumor
Ovarian neoplasms
Carcinoma
