Slit/Robo信号通路在妇科肿瘤发生中的作用

Roles of Slit/Robo Pathway in Gynecological Tumorigenesis

Slit/Robo信号作为神经导向因子在神经系统发育中具有导向轴突生长和排斥神经细胞迁移的重要作用。目前研究发现,Slit/Robo信号也可能参与了肿瘤发生发展中某些关键步骤,如细胞迁移和肿瘤新生血管的形成,但其在妇科肿瘤中的作用尚不清楚。从Slit/Robo信号在女性生殖系统生理、病理状态下的表达情况,以及参与妇科肿瘤发生的机制等方面做一综述。

As important axon guidance molecules,the Slit family of secreted proteins acts through the Roundabout （Robo） receptors to direct axonal growth and repel axonal migration during central nervous system development. Recent research has revealed that the Slit/Robo pathway might play roles in some pivotal processes in tumorigenesis,such as cell migration and tumor angiogenesis. However, the role of Slit/Robo in gynecological tumorigenesis remains largely unknown. This review will examine the roles of this pathway in the physiology and pathology of the reproductive system and highlight areas for future research.